Search result: Catalogue data in Autumn Semester 2018

Biology Master Information
Elective Major Subject Areas
Elective Major: Biological Chemistry
Elective Concept Courses
NumberTitleTypeECTSHoursLecturers
551-0307-00LMolecular and Structural Biology I: Protein Structure and Function Information
D-BIOL students are obliged to take part I and part II (next semester) as a two-semester course
W3 credits2VR. Glockshuber, K. Locher, E. Weber-Ban
AbstractBiophysics of protein folding, membrane proteins and biophysics of membranes, enzymatic catalysis, catalytic RNA and RNAi, current topics in protein biophysics and structural biology.
ObjectiveUnderstanding of structure-function relationships in proteins and in protein folding, detailed understanding of biophysics and physical methods as well as modern methods for protein purification and microanalytics.
Lecture notesScripts on the individual topics can be found under Link.
LiteratureBasics:
- Creighton, T.E., Proteins, Freeman, (1993)
- Fersht, A., Enzyme, Structure and Mechanism in Protein Science (1999), Freeman.
- Berg, Tymoczko, Stryer: Biochemistry (5th edition), Freeman (2001).

Current topics: References will be given during the lectures.

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551-0319-00LCellular Biochemistry (Part I) Information W3 credits2VU. Kutay, Q. Feng, M. Peter, P. Picotti, I. Zemp
AbstractConcepts and molecular mechanisms underlying the biochemistry of the cell, providing advanced insights into structure, function and regulation of individual cell components. Particular emphasis will be put on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes such as intracellular transport, cell division & growth, and cell migration.
ObjectiveThe full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterisation of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry.
The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain the integration of different molecules and signaling pathways into complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, cell division and cell growth. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer.
ContentStructural and functional details of individual cell components, regulation of their interactions, and various aspects of the regulation and compartmentalisation of biochemical processes.
Topics include: biophysical and electrical properties of membranes; viral membranes; structural and functional insights into intracellular transport and targeting; vesicular trafficking and phagocytosis; post-transcriptional regulation of gene expression.
Lecture notesScripts and additional material will be provided during the semester. Please contact Dr. Alicia Smith for assistance with the learning materials. (Link)
LiteratureRecommended supplementary literature (review articles and selected primary literature) will be provided during the course.
Prerequisites / NoticeTo attend this course the students must have a solid basic knowledge in chemistry, biochemistry and general biology. The course will be taught in English.
551-1299-00LIntroduction to Bioinformatics Restricted registration - show details
Number of participants limited to 50.
W6 credits4GS. Sunagawa, M. Gstaiger, A. Kahles, G. Rätsch, B. Snijder, E. Vayena, C. von Mering, N. Zamboni
AbstractThis course introduces principle concepts, the state-of-the-art and methods used in the field of Bioinformatics. Major topics include: genomics, metagenomics, network bioinformatics, and imaging. Lectures are accompanied by practical exercises that involve the use of common bioinformatic methods and basic programming.
ObjectiveThe course will provide students with the theoretical background in the area of genomics, metagenomics, network bioinformatics and imaging. In addition, students will acquire basic skills in applying modern methods that are used in these sub-disciplines of Bioinformatics. Students will thus be able to access and analyze DNA sequence information, construct and interpret networks that emerge though interactions of e.g. genes/proteins, and extract information based on computer-assisted image data analysis. Students will also be able to assess the ethical implications of access to and generation of new and large amounts of information as they relate to the identifiability of a person and the ownership of data.
ContentEthics
Case studies to learn about applying ethical principles in human genomics research

Genomics
Genetic variant calling
Analyze and critical evaluate genome wide association studies

Metagenomics
Reconstruction of microbial genomes
Microbial community compositional analysis
Quantitative metagenomics

Network bioinformatics
Inference of molecular networks
Use of networks for interpretation of (gen)omics data

Imaging
High throughput single cell imaging
Image segmentation
Automatic analysis of drug effects on single cell suspension (chemotyping)
Prerequisites / NoticeBringing your own laptop is a prerequisite for taking this course.
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