Suchergebnis: Katalogdaten im Herbstsemester 2018

Biologie Master Information
Wahlvertiefungen
Wahlvertiefung: Zellbiologie
Wahlpflicht Konzeptkurse
Siehe D-BIOL Master-Wegleitung
NummerTitelTypECTSUmfangDozierende
551-0319-00LCellular Biochemistry (Part I) Information W3 KP2VU. Kutay, Q. Feng, M. Peter, P. Picotti, I. Zemp
KurzbeschreibungConcepts and molecular mechanisms underlying the biochemistry of the cell, providing advanced insights into structure, function and regulation of individual cell components. Particular emphasis will be put on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes such as intracellular transport, cell division & growth, and cell migration.
LernzielThe full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterisation of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry.
The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain the integration of different molecules and signaling pathways into complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, cell division and cell growth. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer.
InhaltStructural and functional details of individual cell components, regulation of their interactions, and various aspects of the regulation and compartmentalisation of biochemical processes.
Topics include: biophysical and electrical properties of membranes; viral membranes; structural and functional insights into intracellular transport and targeting; vesicular trafficking and phagocytosis; post-transcriptional regulation of gene expression.
SkriptScripts and additional material will be provided during the semester. Please contact Dr. Alicia Smith for assistance with the learning materials. (Link)
LiteraturRecommended supplementary literature (review articles and selected primary literature) will be provided during the course.
Voraussetzungen / BesonderesTo attend this course the students must have a solid basic knowledge in chemistry, biochemistry and general biology. The course will be taught in English.
551-0309-00LConcepts in Modern GeneticsW6 KP4VY. Barral, D. Bopp, A. Hajnal, M. Stoffel, O. Voinnet
KurzbeschreibungConcepts of modern genetics and genomics, including principles of classical genetics; yeast genetics; gene mapping; forward and reverse genetics; structure and function of eukaryotic chromosomes; molecular mechanisms and regulation of transcription, replication, DNA-repair and recombination; analysis of developmental processes; epigenetics and RNA interference.
LernzielThis course focuses on the concepts of classical and modern genetics and genomics.
InhaltThe topics include principles of classical genetics; yeast genetics; gene mapping; forward and reverse genetics; structure and function of eukaryotic chromosomes; molecular mechanisms and regulation of transcription, replication, DNA-repair and recombination; analysis of developmental processes; epigenetics and RNA interference.
SkriptScripts and additional material will be provided during the semester.
551-0317-00LImmunology IW3 KP2VM. Kopf, A. Oxenius
KurzbeschreibungEinführung in strukturelle und funktionelle Eigenschaften des Immunsystems.
Grundlegendes Verständnis der Mechanismen und der Regulation einer Immunantwort.
LernzielEinführung in strukturelle und funktionelle Eigenschaften des Immunsystems.
Grundlegendes Verständnis der Mechanismen und der Regulation einer Immunantwort.
Inhalt- Einleitung und historischer Hintergrund
- Angeborene und adaptive Immunantwort, Zellen und Organe des Immunsystems
- B Zellen und Antikörper
- Generation von Diversität
- Antigen-Präsentation und Histoinkompatibilitätsantigene (MHC)
- Thymus und T Zellselektion
- Autoimmunität
- Zytotoxische T Zellen und NK Zellen
- Th1 und Th2 Zellen, regulatorische T Zellen
- Allergien
- Hypersensitivititäten
- Impfungen und immun-therapeutische Interventionen
SkriptDie Studenten haben elekronischen Zugriff auf die Vorlesungsunterlagen. Der Link ist unter "Lernmaterialien" zu finden.
Literatur- Kuby, Immunology, 7th edition, Freemen + Co., New York, 2009
Voraussetzungen / BesonderesImmunology I (WS) und Immunology II (SS) werden in einer Sessionsprüfung im Anschluss an Immunology II als eine Lerneinheit geprüft.
376-1305-10LNeurobiology Information W6 KP4VG. Schratt, E. Stoeckli, L. Filli, W. von der Behrens, weitere Dozierende
KurzbeschreibungEntwicklung des Nervensystems (NS), adultes NS; Plastizität & Regeneration. Sensorische Systeme, Kognitive Funktionen, Lernen und Gedächtnis; molekulare und zelluläre Mechanismen, Tiermodelle, Krankheiten des NS.
LernzielEinblick verschaffen in die normale Entwicklung, die Plastizität und die Regeneration des Nervensystems auf Grund molekularer, zellulärer und biochemischer Ansätze.
InhaltEinblick verschaffen in die normale Entwicklung, die Plastizität und die Regeneration des Nervensystems auf Grund molekularer, zellulärer und biochemischer Ansätze.
SkriptStructure, Plasticity and Repair of the Nervous System (376-1305-01L): Skript wird auf Moodle zur Verfügung gestellt Link
Einschreibeschlüssel wird zur Beginn der Vorlesung zur Verfügung gestellt.

Development of the Nervous System (376-1305-00L): Skript wird auf OLAT zur Verfügung gestellt Link
LiteraturDiese Vorlesung setzt das Lesen von Buchkapiteln, Handouts und Originalliteratur voraus. Weitere Informationen dazu werden in den verschiedenen Vorlesungsstunden abgegeben.
551-1299-00LIntroduction to Bioinformatics Belegung eingeschränkt - Details anzeigen
Number of participants limited to 50.
W6 KP4GS. Sunagawa, M. Gstaiger, A. Kahles, G. Rätsch, B. Snijder, E. Vayena, C. von Mering, N. Zamboni
KurzbeschreibungThis course introduces principle concepts, the state-of-the-art and methods used in the field of Bioinformatics. Major topics include: genomics, metagenomics, network bioinformatics, and imaging. Lectures are accompanied by practical exercises that involve the use of common bioinformatic methods and basic programming.
LernzielThe course will provide students with the theoretical background in the area of genomics, metagenomics, network bioinformatics and imaging. In addition, students will acquire basic skills in applying modern methods that are used in these sub-disciplines of Bioinformatics. Students will thus be able to access and analyze DNA sequence information, construct and interpret networks that emerge though interactions of e.g. genes/proteins, and extract information based on computer-assisted image data analysis. Students will also be able to assess the ethical implications of access to and generation of new and large amounts of information as they relate to the identifiability of a person and the ownership of data.
InhaltEthics
Case studies to learn about applying ethical principles in human genomics research

Genomics
Genetic variant calling
Analyze and critical evaluate genome wide association studies

Metagenomics
Reconstruction of microbial genomes
Microbial community compositional analysis
Quantitative metagenomics

Network bioinformatics
Inference of molecular networks
Use of networks for interpretation of (gen)omics data

Imaging
High throughput single cell imaging
Image segmentation
Automatic analysis of drug effects on single cell suspension (chemotyping)
Voraussetzungen / BesonderesBringing your own laptop is a prerequisite for taking this course.
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